@article { WOS:000750874200022, title = {Sulfation Pattern Dependent Iron(III) Mediated Interleukin-8 Glycan Binding}, journal = {CHEMBIOCHEM}, volume = {23}, year = {2022}, note = {[[{"fid":"256168","view_mode":"default","type":"media","attributes":{"style":"width: 250px; height: 138px;","alt":"122","class":"img-responsive media-element file-default "}}]] }, month = {FEB 4}, abstract = {

Cytokines such as interleukin-8 activate the immune system during infection and interact with sulfated glycosaminoglycans with specific sulfation patterns. In some cases, these interactions are mediated by metal ion binding which can be used to tune surface-based glycan-protein interactions. We evaluated the effect of both hyaluronan sulfation degree and Fe3+ on interleukin-8 binding by electrochemical impedance spectroscopy and surface characterizations. Our results show that sulfation degree and metal ion interactions have a synergistic effect in tuning the electrochemical response of the glycated surfaces to the cytokine.\ 


}, issn = {1439-4227}, doi = {10.1002/cbic.202100552}, author = {Brunori, Francesco and Padhi, Deepak Kumar and Alshanski, Israel and Freyse, Joanna and Duerig, Jan-Niklas and Penk, Anja and Vaccaro, Luigi and Mattan Hurevich and Rademann, Joerg and Yitzchaik, Shlomo} }