@article { WOS:000743206400001, title = {Stirring Peptide Synthesis to a New Level of Efficiency}, journal = {ORGANIC PROCESS RESEARCH \& DEVELOPMENT}, volume = {26}, year = {2022}, note = {[[{"fid":"256172","view_mode":"default","type":"media","attributes":{"style":"width: 250px; height: 230px;","alt":"jj","class":"img-responsive media-element file-default "}}]] }, month = {JAN 21}, pages = {129-136}, abstract = {

Accelerating solid-phase synthesis is crucial for accessing a large number of peptides in a short time. Since standard peptide synthesis is usually done under poor diffusion conditions with slow or no mixing of the solid support, acceleration of the process is achieved by applying a large excess of reagents. In this work, overhead stirring and heating were combined to provide accelerated solid-phase peptide synthesis without using an excess of reagent. A new setup that allows both heating and fast stirring was designed specifically for research laboratory-scale peptide synthesis. By increasing the diffusion of both reagents and beads in a narrow dimension reactor, solid-phase reactions were done in seconds and medium-size peptides were synthesized in minutes.\ 

}, issn = {1083-6160}, doi = {10.1021/acs.oprd.1c00304}, author = {Naoum, Johnny N. and Alshanski, Israel and Mayer, Guy and Strauss, Poriah and Mattan Hurevich} }