@article { WOS:000503484700012, title = {A zinc selective oxytocin based biosensor}, journal = {JOURNAL OF MATERIALS CHEMISTRY B}, volume = {8}, year = {2020}, note = {[[{"fid":"258955","view_mode":"default","type":"media","attributes":{"style":"width: 173px; height: 190px;","alt":"zinc","class":"img-responsive media-element file-default "}}]] }, month = {JAN 7}, pages = {155-160}, abstract = {

Oxytocin is a peptide hormone with high affinity to both Zn2+ and Cu2+ ions compared to other metal ions. This affinity makes oxytocin an attractive recognition layer for monitoring the levels of these essential ions in biofluids. Native oxytocin cannot differentiate between Cu2+ and Zn2+ ions and hence it is not useful for sensing Zn2+ in the presence of Cu2+. We elucidated the effect of the terminal amine group of oxytocin on the affinity toward Cu2+ using theoretical calculations. We designed a new Zn2+ selective oxytocin-based biosensor that utilizes the terminal amine for surface anchoring, also preventing the response to Cu2+. The biosensor shows exceptional selectivity and very high sensitivity to Zn2+ in impedimetric biosensing. This study shows for the first time an oxytocin derived sensor that can be used directly for sensing Zn2+ in the presence of Cu2+.\ 


}, issn = {2050-750X}, doi = {10.1039/c9tb01932d}, author = {Mervinetsky, Evgeniy and Alshanski, Israel and Tadi, Kiran Kumar and Dianat, Arezoo and Buchwald, Joerg and Gutierrez, Rafael and Cuniberti, Gianaurelio and Mattan Hurevich and Yitzchaik, Shlomo} }