@article { WOS:000445711200030, title = {Enhancing the Efficiency of the Solid Phase Peptide Synthesis (SPPS) Process by High Shear Mixing}, journal = {ORGANIC PROCESS RESEARCH \& DEVELOPMENT}, volume = {22}, year = {2018}, note = {[[{"fid":"263807","view_mode":"default","type":"media","attributes":{"style":"width: 300px; height: 225px;","alt":"enhance","class":"img-responsive media-element file-default "}}]] }, month = {SEP}, pages = {1318-1322}, abstract = {

The brittle nature of the polymer beads used in SPPS dictates mild mixing techniques with low mass transfer. We demonstrate that vigorous overhead mechanical stirring with superior mass transfer properties kept the beads intact and significantly accelerates reaction kinetics and efficiency.

}, issn = {1083-6160}, doi = {10.1021/acs.oprd.8b00225}, author = {Alshanski, Israel and Bentolila, Moshe and Gitlin-Domagalska, Agata and Zamir, Dolev and Zorsky, Shir and Joubran, Salim and Mattan Hurevich and Gilon, Chaim} }