@article { WOS:000333477400066, title = {Continuous Photochemical Cleavage of Linkers for Solid-Phase Synthesis}, journal = {ORGANIC LETTERS}, volume = {16}, year = {2014}, note = {[[{"fid":"263831","view_mode":"default","type":"media","attributes":{"style":"width: 300px; height: 96px;","alt":"con","class":"img-responsive media-element file-default "}}]] }, month = {MAR 21}, pages = {1794-1797}, abstract = {

Photo labile linkers are an attractive alternative for solid-phase synthesis because they can be cleaved using light. However, irradiation in a classical batch photoreactor results in incomplete cleavage of the photolabile linkers. It is demonstrated that a continuous flow photoreactor is superior to a batch photoreactor for the cleavage of a linker from polystyrene resin.


}, issn = {1523-7060}, doi = {10.1021/ol500530q}, author = {Mattan Hurevich and Kandasamy, Jeyakumar and Ponnappa, Bopanna M. and Collot, Mayeul and Kopetzki, Daniel and McQuade, D. Tyler and Seeberger, Peter H.} }