@article {doi:10.1021/acs.oprd.2c00164, title = {Accelerated Multiphosphorylated Peptide Synthesis}, journal = {Organic Process Research \& Development}, volume = {26}, year = {2022}, note = {}, pages = {2492-2497}, abstract = {

Preparing phosphorylated peptides with multiple adjacent phosphorylations is synthetically difficult, leads to β-elimination, results in low yields, and is extremely slow. We combined synthetic chemical methodologies with computational studies and engineering approaches to develop a strategy that takes advantage of fast stirring, high temperature, and a very low concentration of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to produce multiphosphorylated peptides at an extremely rapid time and high purity.

}, doi = {10.1021/acs.oprd.2c00164}, author = {Grunhaus, Dana and Molina, Estefan{\'\i}a Rossich and Cohen, Roni and Stein, Tamar and Assaf Friedler and Mattan Hurevich} }