Joint with Prof. Shlomo Yitzchaik

Main research topic:Stirred reactor development for solid phase synthesis and electrochemical biosensing of enzymatic processes

Nonscientific Interests: Tennis, music, traveling, chess, detective fiction and sci-fi literature, and movies

Publications:

(1) Sukhran, Y.; Alshanski, I.; Filiba, O.; Mackintosh, M. J.; Schapiro, I.; Hurevich, M.; Unexpected Nucleophile Masking in Acyl Transfer to Sterically Crowded and Conformationally Restricted Galactosides. J. Org. Chem. 2023, In Press. https://doi.org/10.1021/acs.joc.3c00878

(2) Bakhatan, Y.; Alshanski, I.; Chan, C. K.; Lo, W. C.; Lu, P. W.; Liao, P.H.; Wang, C. C.; Hurevich, M.; Accelerated Solid Phase Glycan Synthesis: ASGS. Chem. Eur. J. 2023, 29, e20230089. https://doi.org/10.1002/chem.202300897

(3) Alshanski, I.; Toraskar, S.; Shitrit, A.; Gordon-Levitan, D.; Jain, P.; Kikkeri, R.; Hurevich, M.; Yitzchaik, S.; Biocatalysis versus Molecular Recognition in Sialoside-Selective Neuraminidase Biosensing. ACS Chem. Biol. 2023, 18, 605-614. https://doi.org/10.1021/acschembio.2c00913

(4) Solomon, O.; Alshanski, I.; Shitrit, A.; Chen, Y.J.; Friedler, A.; Yitzchaik, S.; Using a single peptide to electrochemically sense multiple kinases. Biochemistry 2023, 62, 351-357. https://doi.org/10.1021/acs.biochem.2c00411

(5) Shitrit, A.; Mardhekar, S.; Alshanski, I.; Jain, P.; Raigawali, R.; Shanthamurthy, D. C.; Kikkeri, R.; Yitzchaik, S.; Hurevich, M.; Profiling Heparan Sulfate-Heavy Metal Ions Interaction Using Electrochemical Techniques. Chem. Eur. J. 2022, 28, e20220219. https://doi.org/10.1002/chem.202202193 Inside Cover.

(6) Alshanski, I.; Shitrit, A.; Sukhran, Y.; Unverzagt, C.; Hurevich, M.; Yitzchaik, S.; Effect of interfacial properties on impedimetric biosensing of sialylation process with biantennary N-glycan-based monolayer. Langmuir. 2022, 38 (2), 849–855. https://doi.org/10.1021/acs.langmuir.1c02995

(7) Brunori, F.; Kumar Padhi, D.; Alshanski, I.; Freyse, J.; Dürig, N. J.; Penk, A.; Vaccaro, L.; Hurevich, M.; Rademann, J.; Yitzchaik, S. Sulfation pattern dependent Iron (III) mediated interleukin-8 glycan binding. Chembiochem. 2022, 23, e20210055. https://doi.org/10.1002/cbic.202100552.

(8) Naoum, J.#; Alshanski, I.#; Mayer, G. #; Strauss, P.; Hurevich, M. Stirring Peptide Synthesis to a New Level of Efficiency. Org. Process Res. Dev. 2022. 26(1), 137-143 https://doi.org/10.1021/acs.oprd.1c00304

(9) Alshanski, I.; Shalev, D. E.; Yitzchaik, S.; Hurevich, M. Determining the Structure and Binding Mechanism of Oxytocin Cu2+ Complex Using Paramagnetic Relaxation Enhancement NMR Analysis. J. Biol. Inorg. Chem. 2021, 26, 809–815 https://doi.org/10.1007/s00775-021-01897-1.

(10) Alshanski, I.; Sukhran, Y.; Mervinetsky, E.; Unverzagt, C.; Yitzchaik, S.; Hurevich, M. Electrochemical Biosensing Platform Based on Complex Biantennary N-Glycan for Detecting Enzymatic Sialylation Processes. Biosens. Bioelectron. 2021, 172, 112762. https://doi.org/10.1016/j.bios.2020.112762.

(11) Attia, J.; Nir, S.; Mervinetsky, E.; Balogh, D.; Gitlin-Domagalska, A.; Alshanski, I.; Reches, M.; Hurevich, M.; Yitzchaik, S. Non-Covalently Embedded Oxytocin in Alkanethiol Monolayer as Zn2+ Selective Biosensor. Sci. Rep. 2021, 11 (1), 1–7. https://doi.org/10.1038/s41598-021-85015-w.

(12) Dery, S.#; Alshanski, I.#; Mervinetsky, E.; Feferman, D.; Yitzchaik, S.; Hurevich, M.; Gross, E. The Influence of Surface Proximity on Photoswitching Activity of Stilbene-Functionalized N-Heterocyclic Carbene Monolayers. Chem. Commun. 2021, 57 (51), 6233–6236. https://doi.org/10.1039/d1cc02491d. Inside Cover, Featured in chemical communications HOT articles.

(13) Bakhatan, Y.; Alshanski, I.; Grunhaus, D.; Hurevich, M. The Breaking Beads Approach for Photocleavage from Solid Support. Org. Biomol. Chem. 2020, 18 (22), 4183–4188. https://doi.org/10.1039/d0ob00821d.

(14) Mervinetsky, E.#; Alshanski, I.#; Tadi, K. K.; Dianat, A.; Buchwald, J.; Gutierrez, R.; Cuniberti, G.; Hurevich, M.; Yitzchaik, S. A Zinc Selective Oxytocin Based Biosensor. J. Mater. Chem. B 2020, 8 (1), 155–160. https://doi.org/10.1039/c9tb01932d.

(15) Mervinetsky, E.; Alshanski, I.; Lenfant, S.; Guerin, D.; Medrano Sandonas, L.; Dianat, A.; Gutierrez, R.; Cuniberti, G.; Hurevich, M.; Yitzchaik, S.; Vuillaume, D. Electron Transport through Self-Assembled Monolayers of Tripeptides. J. Phys. Chem. C 2019, 123 (14), 9600–9608. https://doi.org/10.1021/acs.jpcc.9b01082.

(16) Synhaivska, O.; Mermoud, Y.; Baghernejad, M.; Alshanski, I.; Hurevich, M.; Yitzchaik, S.; Wipf, M.; Calame, M. Detection of Cu2+ Ions with GGH Peptide Realized with Si-Nanoribbon ISFET. Sensors 2019, 19 (18), 4022. https://doi.org/10.3390/s19184022.

(17) Naoum, J. #; Alshanski, I.#; Gitlin-Domagalska, A.; Bentolila, M.; Gilon, C.; Hurevich, M. Diffusion Enhanced Amide Bond Formation on Solid Support. Org. Process Res. Dev. 2019, 23, 2733–2739. https://doi.org/10.1021/acs.oprd.9b00398.

(18) Mervinetsky, E.; Alshanski, I.; Buchwald, J.; Dianat, A.; Lončarić, I.; Lazić, P.; Crljen, Ž.; Gutierrez, R.; Cuniberti, G.; Hurevich, M.; Yitzchaik, S. Direct Assembly and Metal - Ions Binding Properties of Oxytocin Monolayer on Gold Surfaces. Langmuir 2019, 35 (34), 11114–11122. https://doi.org/10.1021/acs.langmuir.9b01830. Inside Cover.

(19) Alshanski, I.; Blaszkiewicz, J.; Mervinetsky, E.; Rademann, J.; Yitzchaik, S.; Hurevich, M. Sulfation Patterns of Saccharides and Heavy Metal Ions Binding. Chem. Eur. J. 2019, 25 (52), 12083–12090. https://doi.org/10.1002/chem.201901538. Inside Cover.

(20) Gankin, A.; Mervinetsky, E.; Alshanski, I.; Buchwald, J.; Dianat, A.; Gutierrez, R.; Cuniberti, G.; Sfez, R.; Yitzchaik, S. ITO Work Function Tunability by Polarizable Chromophore Monolayers. Langmuir 2019, 35, 2997–3004. https://doi.org/10.1021/acs.langmuir.8b03943.

(21) Tadi, K. K.; Alshanski, I.; Hurevich, M.; Yitzchaik, S. PH Controlled Impedimetric Sensing of Copper (II) Ion Using Oxytocin as Recognition Element. Surfaces 2018, 1 (1), 90–95. https://doi.org/10.3390/surfaces1010008.

(22) Samarasimhareddy, M.; Alshanski, I.; Mervinetsky, E.; Hurevich, M.; Photodeprotection of up to Eight Photolabile Protecting Groups from a Single Glycan. Synlett 2018, 29 (07), 880–884. https://doi.org/10.1055/s-0036-1591915.

(23) Alshanski, I.; Bentolila, M.; Gitlin-Domagalska, A.; Zamir, D.; Zorsky, S.; Joubran, S.; Hurevich, M.; Gilon, C. Enhancing the Efficiency of the Solid Phase Peptide Synthesis (SPPS) Process by High Shear Mixing. Org. Process Res. Dev. 2018, 22, 1318–1322. https://doi.org/10.1021/acs.oprd.8b00225.

(24) Bentolila, M.; Alshanski, I.; Novoa, R.; Gilon, C. Optimization of Chemical Processes by the Hydrodynamic Simulation Method (HSM). Chemengineering 2018, 2 (2), 21. https://doi.org/10.3390/chemengineering2020021.

(25) Mervinetsky, E.; Alshanski, I.; Hamo, Y.; Sandonas, L. M.; Dianat, A.; Buchwald, J.; Gutierrez, R.; Cuniberti, G.; Hurevich, M.; Yitzchaik, S. Copper Induced Conformational Changes of Tripeptide Monolayer Based Impedimetric Biosensor. Sci. Rep. 2017, 7 (1), 1–7. https://doi.org/10.1038/s41598-017-10288-z.

(26) Tadi, K. K.; Alshanski, I.; Mervinetsky, E.; Marx, G.; Petrou, P.; Dimitrios, K. M.; Gilon, C.; Hurevich, M.; Yitzchaik, S. Oxytocin-Monolayer-Based Impedimetric Biosensor for Zinc and Copper Ions. ACS Omega 2017, 2 (12), 8770–8778. https://doi.org/10.1021/acsomega.7b01404.

(27) Amiel, D. B. A.; Alshanski, I.; Hurevich, M. Automated Oligosaccharide Synthesis: Development of the Glyconeer®. Comprehensive Glycoscience, 2nd ed.; Elsevier B.V., 2021, 548-560. https://doi.org/10.1016/b978-0-12-819475-1.00069-9