People

Current Members

David

David Nessim

M.Sc student
Los Angeles Building; Room 314 Givat Ram Campus Jerusalem ,91904, Israel
grigory

Grigory Zutler

B.Sc
Los Angeles Building; Room 314 Givat Ram Campus Jerusalem ,91904, Israel
Hen

Hen Okshtein

M.Sc student
Los Angeles Building; Room 318 Givat Ram Campus Jerusalem ,91904, Israel

Mattan Hurevich

mattan_hurevich_staff_photo
Prof.
Mattan
Hurevich
Associate Professor at The Hebrew University of Jerusalem, Faculty of Science, The Institute of Chemistry
Los Angeles Building; Room 312 Givat Ram Campus Jerusalem ,91904, Israel
972-26586201
mattan.hurevich@mail.huji.ac.il
ORCID
google scholar

B.Sc., 2001, The Hebrew University of Jerusalem; M.Sc., 2004, The Hebrew University of Jerusalem Ph.D., 2010, The Hebrew University of (advisor: Chaim Gilon); Postdoctoral Training, 2010-2014, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany (advisor: Peter H. Seeberger); 2015-2017, Senior scientists, The Hebrew University of Jerusalem; Assistant Professor, 2017-present, The Hebrew University of Jerusalem 

Research interests:

Automated and photochemical synthesis of oligosaccharides, N- / O- glycopeptides Syntheses of multi phosphorylated peptides Development of biosensors based on oligosaccharide, peptides and glycopeptides Enzymatic glycosylation and hydrolysis of oligosaccharides

 

•Automated glycan assembly using the Glyconeer 2.1 synthesizer. Hahm, H.S., et al. PNAS., 114, 3385-3389 (2017).

•Automated assembly of oligosaccharides containing multiple cis-glycosidic linkages. Hahm, H.S., et al. Nat Comm., 7, 12482 (2016).

•Automated glycopeptide assembly by combined solid-phase peptide and oligosaccharide synthesis. Hurevich, M., et al. Chem Comm., 50, 1851-1853 (2014).

Personal details: Mattan was born and lives in Jerusalem, Israel. He is married and a proud father of two lovely daughters. His non-scientific time is devoted to Manchester United, Tom Waits, hiking, camping and reading books.

Selected publications:

•A zinc selective oxytocin based biosensor. Mervinejsky, E., et al. J Mat Chem B., 8, 155-160 (2020).

•The Breaking Beads Approach for Photocleavage from Solid Support.  Bakhatan et al. Org Biomol Chem, in press

•Diffusion enhanced amide bond formation on solid support. Naoum, J., et al. ACS Org Proc Res Dev., 23, 2733-2739 (2019).

•Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation. Mayer, D., et al. Nat Comm., 10, 1261 (2019).

•A targeted approach for the synthesis of multi-phosphorylated peptides: a tool for studying the role of phosphorylation patterns in proteins. Samarasimhareddy, M., et al. Org Biomol Chem., 14, 1860-1865 (2019).

•Sulfation Patterns of Saccharides and Heavy Metal Ion Binding. Alshanski, I., et al. Chem Eur J., 25, 12083-12090 (2019).

•Direct Assembly and Metal-Ion Binding Properties of Oxytocin Monolayer on Gold Surfaces. Mervinejsky, E., et al. Langmuir., 35, 11114-11122 (2019).

•Electron Transport through Self-Assembled Monolayers of Tripeptides.. Mervinetsky, E., et al. JPCC., 123, 9600-9608 (2019).

•Enhancing the Efficiency of the Solid Phase Peptide Synthesis (SPPS) Process by High Shear Mixing. Alshanski, I., et al. ACS Org Proc Res Dev., 22, 1318-1322 (2018).

 

Principle Investigator Current Members

Yuval Farchy

yuval
Yuval
Farchy
Ph.D. candidate
Los Angeles Building; Room 314 Givat Ram Campus Jerusalem ,91904, Israel
yuval.farchy@mail.huji.ac.il

B.Sc in the joint program for chemistry and biology, The Hebrew University of Jerusalem.

M. Sc student for Chemistry . 

Main research topic:synthesis of proteoglycan core glycan

Hobbies:Basktball, Tennis, Creative writing, D&D, Fountain pens and Inks, home-brewing, restorations

MSc students Current Members

Yonatan Sukhran

yonatan
Yonatan
Sukhran
Ph.D. candidate
Los Angeles Building; Room 314 Givat Ram Campus Jerusalem ,91904, Israel
yonatan.sukhran@mail.huji.ac.il

Completed  B.Sc. double major in Chemistry and Life Sciences at The Hebrew University of Jerusalem in 2021, and  M.Sc. in Organic Chemistry at The Hebrew University of Jerusalem in 2023.

 Main Current research topic: solid phase synthesis of a library of sulfated carrageenans.

Nonscientific Interests: Woodworking and origami.

Publications:

(1) Sukhran, Y.; Alshanski, I.; Filiba, O.; Mackintosh, M. J.; Schapiro, I.; Hurevich, M.; Unexpected Nucleophile Masking in Acyl Transfer to Sterically Crowded and Conformationally Restricted Galactosides. J. Org. Chem. 2023,88 (13),9313-9320. https://doi.org/10.1021/acs.joc.3c00878.

(2) Bakhatan, Y.; Ben Abba Amiel, D.; Sukhran, Y.; Chan, C. K.; Lo, W. C.; Lu, P. W.; Liao, P. H.; Wang, C. C.; Hurevich, M. Translating Solution to Solid Phase Glycosylation Conditions. Chem. Commun. 2022, 58 (80), 11256–11259. https://doi.org/10.1039/D2CC03831E.

(3)Alshanski, I.; Shitrit, A.; Sukhran, Y.; Unverzagt, C.; Hurevich, M.; Yitzchaik, S.; Effect of interfacial properties on impedimetric biosensing of sialylation process with biantennary N-glycan-based monolayer. Langmuir. 2022, 38 (2), 849–855. https://doi.org/10.1021/acs.langmuir.1c02995.

(4) Alshanski, I.; Sukhran, Y.; Mervinetsky, E.; Unverzagt, C.; Yitzchaik, S.; Hurevich, M. Electrochemical Biosensing Platform Based on Complex Biantennary N-Glycan for Detecting Enzymatic Sialylation Processes. Biosens. Bioelectron. 2021, 172, 112762. https://doi.org/10.1016/j.bios.2020.112762.

 

PhD students Current Members

Dror Ben Abba Amiel

dror_ben_abba_pic_01
Dror
Ben Abba Amiel
Ph. D candidate
Los Angeles Building; Room 314 Givat Ram Campus Jerusalem ,91904, Israel
dror.benabba@mail.huji.ac.il

Dror was born and lives in Jerusalem. He is married, and is a fan of basketball, hiking, nature photography and cooking. Academic career: B.Sc, 2016, Joint program for physics and chemistry, Hebrew University of Jerusalem; M.Sc, 2019, Hebrew University of Jerusalem. His Current research concerns synthesis of glycopeptide libraries.

Publications:

(1) Ben Abba Amiel, D.; Kim, C.; Gidron, O. Oligofuran–Benzothiadiazole Co-Oligomers: Synthesis, Optoelectronic Properties and Reactivity. Org. Mater. 2021, 03 (02), 303–308. https://doi.org/10.1055/s-0041-1729853.

(2) Ben Abba Amiel, D.; Alshanski, I.; Hurevich, M. Automated Oligosaccharide Synthesis: Development of the Glyconeer®. Compr. Glycosci. 2021, 548–560. https://doi.org/10.1016/B978-0-12-819475-1.00069-9

 

PhD students Current Members

Roey Meir

roi
Roey
Meir
Undergraduate student
Los Angeles Building; Room 314 Givat Ram Campus Jerusalem ,91904, Israel
roey.meir@mail.huji.ac.il

 B.Sc student majoring in chemistry with a minor in biochemistry at The Hebrew University of Jerusalem.

Main research topic: Glycosilation optimization and BB synthesis

Hobbies including reading, gardening, photography, calligraphy, playing guitar, winemaking, aviation, bookbinding, electronics, knitting and sewing

Undergraduate students Current Members

David Nessim

David
David
Nessim
M.Sc student
Los Angeles Building; Room 314 Givat Ram Campus Jerusalem ,91904, Israel

B.Sc in chemistry, Universidad del Valle de México, México, D.F.

M.Sc in chemistry. 

Main research topic: N-Glycans 

Hobbies:Theater

 

MSc students Current Members

Grigory Zutler

grigory
Grigory
Zutler
B.Sc
Los Angeles Building; Room 314 Givat Ram Campus Jerusalem ,91904, Israel

B.Sc student in chemistry and mathematics 

Main research topic:Synthesis of sulfonated derivatives of galactose

Hobbies:Reading, painting, traveling

 

 

Undergraduate students Current Members

Hen Okshtein

Hen
Hen
Okshtein
M.Sc student
Los Angeles Building; Room 318 Givat Ram Campus Jerusalem ,91904, Israel

 

B.sc in biochemistry and food science.

 

Main research topic: glycan&peptide based bio-sensors

Hobbies:Reading, Cooking, baking, solid state fermentation

 

 

MSc students Current Members