Citation:
Grunhaus, D. ; Molina, E. R. ; Cohen, R. ; Stein, T. ; Friedler, A. ; Hurevich, M. . Accelerated Multiphosphorylated Peptide Synthesis. Organic Process Research & Development 2022, 26, 2492-2497.
Abstract:
Preparing phosphorylated peptides with multiple adjacent phosphorylations is synthetically difficult, leads to β-elimination, results in low yields, and is extremely slow. We combined synthetic chemical methodologies with computational studies and engineering approaches to develop a strategy that takes advantage of fast stirring, high temperature, and a very low concentration of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to produce multiphosphorylated peptides at an extremely rapid time and high purity.
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