Continuous Photochemical Cleavage of Linkers for Solid-Phase Synthesis

Citation:

Hurevich, M. ; Kandasamy, J. ; Ponnappa, B. M. ; Collot, M. ; Kopetzki, D. ; McQuade, D. T. ; Seeberger, P. H. . Continuous Photochemical Cleavage Of Linkers For Solid-Phase Synthesis. ORGANIC LETTERS 2014, 16, 1794-1797.

Date Published:

MAR 21

Abstract:

Photo labile linkers are an attractive alternative for solid-phase synthesis because they can be cleaved using light. However, irradiation in a classical batch photoreactor results in incomplete cleavage of the photolabile linkers. It is demonstrated that a continuous flow photoreactor is superior to a batch photoreactor for the cleavage of a linker from polystyrene resin.


 

Notes:

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Last updated on 09/04/2023